Rafat M. Mohareb
Cairo University, Egypt
Title: Uses of cyclohexanediones for the synthesis of nitrogen and/or sulfur heterocyclic compounds together with their cytotoxic evaluations
Biography
Biography: Rafat M. Mohareb
Abstract
In organic chemistry, due to their many applications, derivatives of thiophene stand out among biomolecules used in trials to determine biological activity. They are present in natural products and are frequently incorporated into agrochemicals, dyes, and drugs in general. Various thiophene derivatives are produced by molecular modifications through varied synthesis routes that result in increases in specificity and thus safety profiles. Within the thiophenic family, the 2-amino-thiophenes have been well reported. In new drugs investigations they occupy a special position due to innovations in their synthesis (Gewald reaction), availability, stability, and structural simplicity that allow them to be important scaffolds in chemical and therapeutic products; like the top selling drugs olanzapine and tinoridine. In addition, they present a large spectrum of biological properties that include antimicrobial, anti-inflammatory antioxidant and antiplatelet activities. In the present work we demonstrated the uses of cyclohexane-1,3-dione and cyclohexane-1,4-dione for the synthesis of thiophene, pyrazole and pyran derivatives.